The Commissioners on the part of the United States were William Clark, Ninian Edwards and Auguste Choteau, of St. Louis, Missouri and the treaty was simply one of peace, with no boundaries being established.

On August 4, 1824, the Ioway, by their deputies, Mah-hos-kah (or White Cloud) and Mah-ne-hah-nah (Great Walker), in consideration of the sum of $500 to be paid to the tribe for ten successive years, ceded to the United States all claim to their land in which they had to the "lands in Missouri, situated between the Mississippi and Missouri Rivers, and a line running from the Missouri River, at the mouth or entrance of Kansas River, north 100 miles to the northeast corner of the limits of the State of Missouri, and from there east to the Mississippi River."

They  were then relocated to a reservationin Brown County, Kansas, and Richardson County, Nebraska,  led by their Chief Chief White Cloud. Others settled in a strip of land in Missouri, along with the Sak and Fox, but numerous discontented individuals removed to present-day Oklahoma in 1838.

By a treaty of May, 1854, in common with the Sac and Fox, they ceded to the Government a large portion of their reserve in Kansas and Nebraska, and on October 1, 1859, the tribe, "having now more lands than are necessary for their occupancy and use, and being desirous of promoting settled habits of industry and enterprise among themselves by abolishing the tenure in common by which they hold their lands," cede the reservation to the United States, excepting a tract of twenty miles by twelve, and containing about 153,600. Out of this reservation, a tract of eighty acres to be assigned to every individual of the tribe, the residue to be owned by the tribe in common.

In the years following, discontent grew as the Ioway endeavored to survive the small Kansas land base in Kansas and in 1878 some of the Ioway moved to Indian Territory. The Iowa Tribe of Oklahoma reservation was officially established by an Executive Order dated August 15, 1883 about one mile south of Perkins, Oklahoma. However, the Dawes Severalty Act of 1887 assigned individual Indians tracts of land and in 1890, the Ioway were forced to sell their surplus reservation land which was soon settled by white settlers.